Chemical and Pharmaceutical Bulletin

Synthesis, structure analysis and cytotoxicity studies of novel unsymmetrically N, N'-substituted ureas from dehydroabietic Acid

X Rao, Z Song, L He, W Jia

Index: Rao, Xiaoping; Song, Zhanqian; He, Ling; Jia, Weihong Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 11 p. 1575 - 1578

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Citation Number: 25

Abstract

A series of novel unsymmetrically N, N′-substituted ureas were synthesized from dehydroabietic acid and their structures were characterized by IR, 1 H-NMR, 13 C-NMR spectroscopy and single crystal X-ray diffraction. Three six-membered rings of urea 4c exhibited plane, half-chair and chair configurations, respectively. Their cytotoxicity activities against SMMC7721 liver cancer cells were evaluated by MTT (3-(4, 5-dimethylthiazol-2-yl) ...