Ni-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP

A Rossello, E Nuti, P Carelli, E Orlandini…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 5 p. 1321 - 1326

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Citation Number: 34

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... favour lipophilic interactions with the nearby S1 region of the enzyme site, reinforcing the binding of the planned new inhibitors to the active site of MMP-2. Moreover, in the case of the targeted MMP-14, this chemical manipulation of ...

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