Directed (R)??or (S)??Selective Dynamic Kinetic Enzymatic Hydrolysis of 1, 2, 3, 4??Tetrahydroisoquinoline??1??carboxylic Esters

…, A Liljeblad, LT Kanerva, E Forró…

Index: Paal, Tihamer A.; Liljeblad, Arto; Kanerva, Liisa T.; Forro, Eniko; Fueloep, Ferenc European Journal of Organic Chemistry, 2008 , # 31 p. 5269 - 5276

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Citation Number: 12

Abstract

Abstract The first synthesis of both enantiomers of 6, 7-dimethoxy-1, 2, 3, 4- tetrahydroisoquinoline-1-carboxylic acid was accomplished through dynamic kinetic resolution in procedures based on CAL-B-or subtilisin Carlsberg-catalysed enantioselective hydrolysis of the corresponding ethyl esters in aqueous NH 4 OAc buffer at pH 8.5. The products were obtained with high enantiopurity (92–93% ee) in good yields (85–92%).(R)- ...