Chemoenzymatic synthesis of enantiomerically pure alkene 1, 2-diols and glycosides thereof
T Ziegler, F Bien, C Jurisch
Index: Ziegler, Thomas; Bien, Frank; Jurisch, Claus Tetrahedron Asymmetry, 1998 , vol. 9, # 5 p. 765 - 780
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Citation Number: 44
Abstract
The kinetic resolution of racemic 2-O-acylated 3-butene-1, 2-diol and 1-O-acylated 3-butene- 1, 2-diol derivatives by enzymatic saponification and enzymatic esterification, respectively, is investigated with several lipases and esterases. The resulting partially blocked enantiomers are glycosylated with glycosyl halides and trichloroacetimidates, respectively.
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Chemoenzymatic synthesis of enantiomerically pure alkene 1, 2-diols and glycosides thereof
[Tetrahedron Asymmetry, , vol. 9, # 5 p. 765 - 780]