Collection of Czechoslovak Chemical Communications

Preparation of aliphatic analogues of S-adenosyl-L-homocysteine and related compounds

A Holý

Index: Holy Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 12 p. 3134 - 3144

Full Text: HTML

Citation Number: 1

Abstract

Abstract Reaction of 9-((RS)-2, 3-dihydroxypropyl) adenine (I) with p-toluenesulfonyl chloride afforded the 3-Op-toluenesulfonyl derivative II which on treatment with 2, 3- dihydropyran was transformed into the 3-Op-toluenesulfonyl-2-O-tetrahydropyranyl derivative III. Reaction of II with sodium isobutyl mercaptide in liquid ammonia gave 9-((RS)- 3-isobutylthio-2-hydroxypropyl) adenine (IV). Analogously, compound III and disodium salt ...