Catalyst recognition of cis-1, 2-diols enables site-selective functionalization of complex molecules
X Sun, H Lee, S Lee, KL Tan
Index: Sun, Xixi; Lee, Hyelee; Lee, Sunggi; Tan, Kian L. Nature Chemistry, 2013 , vol. 5, # 9 p. 790 - 795
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Citation Number: 6
Abstract
Carbohydrates and natural products serve essential roles in nature, and also provide core scaffolds for pharmaceutical agents and vaccines. However, the inherent complexity of these molecules imposes significant synthetic hurdles for their selective functionalization and derivatization. Nature has, in part, addressed these issues by employing enzymes that are able to orient and activate substrates within a chiral pocket, which increases dramatically ...
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