Synthesis and evaluation of 7-substituted-3, 4-dihydrobenzo [f][1, 4] oxazepin-5 (2H)-ones as anticonvulsant and hypnotic agents

XQ Deng, MX Song, CX Wei, ZG Sun…

Index: Deng, Xian-Qing; Song, Ming-Xia; Wei, Cheng-Xi; Sun, Zhi-Gang; Quan, Zhe-Shan Medicinal Chemistry Research, 2011 , vol. 20, # 7 p. 996 - 1004

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Abstract

Abstract A series of 7-substituted-3, 4-dihydrobenzo [f][1, 4] oxazepin-5 (2 H)-ones was synthesized. The anticonvulsant effect and neurotoxicity of the compounds were evaluated with a maximal electroshock (MES) test and a rotated test in mice, respectively. Most of the compounds prepared exhibited anticonvulsant activities in the MES test, 7-(heptyloxy)-3, 4- dihydrobenzo [f][1, 4] oxazepin-5 (2 H)-one (10) was the most active. In the anti-MES ...