Discovery of novel tricyclic compounds as squalene synthase inhibitors

M Ichikawa, M Ohtsuka, H Ohki, N Haginoya…

Index: Bioorganic and Medicinal Chemistry, , vol. 20, # 9 p. 3072 - 3093

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Citation Number: 10

Abstract

... Bioorganic & Medicinal Chemistry. ... 3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, were regarded as the first line medicine for the ... Medicinal chemistry efforts to identify small and efficient squalene synthase inhibitors have been reported by some research ...