Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia
CJ Helal, Z Kang, X Hou, J Pandit…
Index: Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4536 - 4547
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Citation Number: 33
Abstract
... Journal of Medicinal Chemistry. ... With an interest in being able to examine the effect of a PDE10A inhibitor in a clinical setting, we sought to bring forward a number of structurally diverse chemical series that would increase the chances of finding a compound with the ...
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