Cardiotonic agents. 3. Synthesis and biological activity of novel 6-(substituted 1H-imidazol-4 (5)-yl)-3 (2H)-pyridazinones

…, G Bobowski, JA Bristol, RE Weishaar…

Index: Sircar; Bobowski; Bristol; Weishaar; Evans Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 261 - 267

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Citation Number: 24

Abstract

(25a) and 6-(l-methyl-2-phenyl-lH-imidazol-4-yl)-3 (~-pyridazinone (28a) were potent positive inotropic agents. By contrast, the corresponding 1H-imidazol-5-yl regioisomers 25b and 28b were only weak positive inotropic agents. Compounds 25a and 28a were also potent inhibitors of cardiac phosphodiesterase fraction 111.

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