Tetrahedron Letters

New synthesis of 2-methyleneaziridines and 2-methyleneazetidines by dimethyl titanocene mediated methylenation of α-and β-lactams

KA Tehrani, N De Kimpe

Index: Abbaspour Tehrani, Kourosch; De Kimpe, Norbert Tetrahedron Letters, 2000 , vol. 41, # 12 p. 1975 - 1978

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Citation Number: 27

Abstract

2-Methyleneazetidines and 2-methyleneaziridines belong to a group of strained cyclic enamines for which little information is available. The unique combination of functionalities, ie a reactive enamine and an exocyclic double bond, offers possibilities for further manipulation. To explore their reactivity and utility, ready access to 2-alkylideneazetidines and -aziridines is necessary. Only a few routes to functionalized 2-methyleneazetidines have been ...