… receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl) amino] phenyl] methyl] imidazole derivatives as angiotensin II …

I Sircar, RT Winters, J Quin III, GH Lu…

Index: Sircar; Winters; Quin III; Lu; Major; Panek Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1735 - 1745

Full Text: HTML

Citation Number: 22

Abstract

A novel series of non-biphenylyltetrazole angiotensin I1 receptor antagonists which contain a 1H-pyrrol-1-ylacetyl residue in place of the benzoyl residue in EXP 6803 have been developed. The receptor binding activity of several members of this new series was in the lW M range, which was better than that of EXP 6803. Introduction of a carboxylic acid moiety at the 2-position of the pyrrole ring enhanced the in vitro binding affinity at the receptor by 10 ...