Journal of the American Chemical Society

Unwinding of supercoiled DNA by platinum-ethidium and related complexes

MV Keck, SJ Lippard

Index: Keck; Lippard Journal of the American Chemical Society, 1992 , vol. 114, # 9 p. 3386 - 3390

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Citation Number: 279

Abstract

Abstract: A gel electrophoretic mobility shift assay has been used to determine the unwinding of closed circular, supercoiled pUC 19 plasmid DNA induced by a variety of platinum complexes that differ in their coordination mode to the double helix. Included are the anticancer drug cisplatin and several of its analogues, compounds in which the organic intercalator ethidium is coordinated to platinum through an exocyclic amino group, and ...