Synthesis in the tropane class of alkaloids. Pseudotropine and dl-cocaine

JJ Tufariello, GB Mullen, JJ Tegeler…

Index: Tufariello,J.J. et al. Journal of the American Chemical Society, 1979 , vol. 101, p. 2435 - 2442

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Citation Number: 143

Abstract

Abstract: A nitrone-based entry into the tropane class of alkaloids is described. Syntheses of pseudotropine and dl-cocaine are discussed. The synthetic utility and the high degree of regiochernical and stereochemical control inherent in the nitrone cycloadditions are stressed.