MAOS protocols for the general synthesis and lead optimization of 3, 6-disubstituted-[1, 2, 4] triazolo [4, 3-b] pyridazines
…, EP Lebois, LM Lewis, NT Nalywajko, CM Niswender…
Index: Aldrich, Leslie N.; Lebois, Evan P.; Michelle Lewis; Nalywajko, Natalia T.; Niswender, Colleen M.; David Weaver; Jeffrey Conn; Lindsley, Craig W. Tetrahedron Letters, 2009 , vol. 50, # 2 p. 212 - 215
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Citation Number: 14
Abstract
General, high-yielding MAOS protocols for the expedient synthesis of functionalized 3, 6- disubstituted-[1, 2, 4] triazolo [4, 3-b] pyridazines are described amenable to an iterative analog library synthesis strategy for the lead optimization of an M1 antagonist screening hit. Optimized compounds proved to be highly selective M1 antagonists.
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