ANTIPYRETIC, ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF CERTAIN γ-OXOBUTANOIC ACID DERIVATIVES

…, KM Youssef, AAE Ahmed, HH Al-Zuhair

Index: Abouzid, Khaled A. M.; Youssef, Khairia M.; Ahmed, Amany A. E.; Al-Zuhair, Hanaa Hussain Medicinal Chemistry Research, 2005 , vol. 14, # 1 p. 26 - 39

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Citation Number: 4

Abstract

Abstract Three chemical entities were synthesized as analogs of fenbufen as well as open ring analog of suldinac and celecoxib. The new compounds were evaluated for antipyretic, antinociceptive and anti-inflammatory activities. Among these compounds, 6-benzo [1, 3] dioxol-5-yl-4-oxo-hex-5-enoic acid (3) was the most active one.