2, 5-Disubstituted-1, 3, 4-oxadiazoles: thymidine phosphorylase inhibitors

…, M Ali, S Hussain, S Perveen, MI Choudhary

Index: Khan, Khalid Mohammed; Rani, Mubeen; Ambreen, Nida; Ali, Muhammad; Hussain, Sajjad; Perveen, Shahnaz; Choudhary, Muhammad Iqbal Medicinal Chemistry Research, 2013 , vol. 22, # 12 p. 6022 - 6028

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Citation Number: 2

Abstract

Abstract A series of 2, 5-disubstituted-1, 3, 4-oxadiazoles (1–16) were synthesized via microwave irradiation and screened against thymidine phosphorylase enzyme. Four members of the series have demonstrated thymidine phosphorylase inhibitory activities with IC 50 values between 37 and 320 μM. Pyridinyl-containing 1, 3, 4-oxadiazoles exhibited an enhanced inhibitory potential, while phenyl analogs did not show substantial inhibitory ...