The Journal of Organic Chemistry

α-Amino Acid Amides. A Convenient Synthesis1

HE JOHNSON, DG CROSBY

Index: Johnson,H.E.; Crosby,D.G. Journal of Organic Chemistry, 1962 , vol. 27, p. 798 - 802

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Citation Number: 12

Abstract

The course of the reaction is critically dependent upon the alcohol that is used for solvent. If R1= H and Rz= H or alkyl then the alcohol RaOH must be secondary; otherwise ester formation results. When R1 and Rz are both alkyl, RaOH mwt be primary in order for any reaction to take place. These and related effects as well as the probable reaction mechanism are discussed.