Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2, 5-diones

K Kamiński, J Obniska, I Chlebek, B Wiklik…

Index: Kaminski, Krzysztof; Obniska, Jolanta; Chlebek, Iwona; Wiklik, Beata; Rzepka, Sabina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6821 - 6830

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Citation Number: 18

Abstract

Abstract The synthesis and anticonvulsant properties of new N-Mannich bases of 3-phenyl- (9a–d), 3-(2-chlorophenyl)-(10a–d), 3-(3-chlorophenyl)-(11a–d) and 3-(4-chlorophenyl)- pyrrolidine-2, 5-diones (12a–d) were described. The key synthetic strategies involve the formation of 3-substituted pyrrolidine-2, 5-diones (5–8), and then aminoalkylation reaction (Mannich-type) with formaldehyde and corresponding secondary amines, which let to ...