Bioorganic & medicinal chemistry

Comparison of demetalation properties between zinc chlorin and zinc porphyrin derivatives: Effect of macrocyclic structures

Y Saga, S Hojo, Y Hirai

Index: Saga, Yoshitaka; Hojo, Sayaka; Hirai, Yuki Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5697 - 5700

Full Text: HTML

Citation Number: 10

Abstract

Metalloporphyrins and metallochlorins are important biological molecules in nature. To examine the effect of macrocyclic structures on removal of central metals from these cyclic tetrapyrrole molecules without peripheral substitution effects, demetalation of zinc methyl pyropheophorbide a (zinc chlorin 1) and zinc methyl protopyropheophorbide a (zinc porphyrin 2) was kinetically analyzed under acidic conditions. Both 1 and 2 exhibited ...