Hydrogen bromide cleavage of hindered 2-methoxyacetophenones
WJ Horton, JT Spence
Index: Horton; Spence Journal of the American Chemical Society, 1958 , vol. 80, p. 2453,2456
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Citation Number: 13
Abstract
The facile cleavage of 3-substituted-2-methoxyacetophenones is ascribed to the steric influence of the 3-substituent. The rate of cleavage of a number of such compounds has been determined and these data as well as ultraviolet spectra isupport the proposal of steric inhibition of resonance by the 3-substituent.
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[Kuleshyus, V. A.; Gaidyalis, P. G.; Pyatrauskas, O. Yu.; Daukshas, V. K. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 7 p. 551 - 553 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 7 p. 827 - 830]