New practical synthesis of prazosin

E Honkanen, A Pippuri, P Kairisalo…

Index: Honkanen; Pippuri; Kairisalo; et al. Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 4 p. 797 - 798

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Citation Number: 11

Abstract

Abstract A new four step synthesis of prazosin, 2-[4-(2-furoyl) piperazin-l-yl]-4-amino-6, 7- dimethoxyquinazoline, has been described. The method is also adaptable for the preparation of other substituted 4-aminoquinazolines. The yields are good in every step and the reactions are performed with ease. Prazosin hydrochloride of high purity is obtained directly in the last step.