Cyclic guanidines. 14. Imidazo [1, 2-a] thienopyrimidin-2-one derivatives as blood platelet aggregation inhibitors

F Ishikawa, A Kosasayama, H Yamaguchi…

Index: Ishikawa, Fumiyoshi; Kosasayama, Akira; Yamaguchi, Hitoshi; Watanabe, Yoshifumi; Saegusa, Junji; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 376 - 382

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Citation Number: 31

Abstract

A series of novel 1, 2, 3, 5-tetrahydroimidazo [l, 2-a] thieno [2, 3-d]-,-[3, 2-d]-, and-[3, 4-d] pyrimidin-2-one derivatives has been prepared and tested for the activity of inhibiting platelet aggregation in rata in vitro and ex vivo. These compounds were synthesized through the following reactions: sodium borohydride reduction of 2, 4-dichlorothienopyrimidines, followed by ethoxycarbonylmethylation and successive amination. Most of the compounds ...