Antineoplastic agents. XXVIII. Camptothecin. delta.-lactone

GR Pettit, RJ Quinn, TH Smith, P Brown…

Index: Pettit; Quinn; Smith; Brown The Journal of organic chemistry, 1972 , vol. 37, # 17 p. 2789 - 2791

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Citation Number: 2

Abstract

(ethyl a, y-dicarbethoxy-a-glutac~ nate),~ which was ethylated directly to give ethyl a, y- dicarbethoxy-aethylgl~ taconate.~ Treatment of the latter compound with 1 molar equiv of sodium ethoxide was reported to yield triester 3a in 95% yield. 4 However, the decarbethoxylat> ion reaction was accompanied, under a variety of reaction conditions, by the formation of diethyl ethylmalonate. In our hands, this competing mode of reaction ...