Interaction and reactivity of carcinogenic N-acetyl-N-(acyloxy)-2-aminofluorene with deoxyguanosine. An intramolecular approach

…, A Leterme, MF Lhomme, J Lhomme

Index: Defrancq, Eric; Pelloux, Nadia; Leterme, Anne; Lhomme, Marie-France; Lhomme, Jean Journal of Organic Chemistry, 1991 , vol. 56, # 16 p. 4817 - 4819

Full Text: HTML

Citation Number: 9

Abstract

Summary: Solvolysis of 3 in watertlcetone mixtures yields the" adduct" 4 (65% in water) with product and rate data consistent with the hypothesis that hydrophobic guanine-fluorene stacking, similar to that which occurs when the carcinogenic aminofluorene metabolite is ...

Related Articles:

A new short and efficient synthetic route to C8-N-acetylarylamine 2′-deoxyguanosine phosphoramidites

[Boege, Nicolas; Krueger, Sarah; Schroeder, Marcus; Meier, Chris Synthesis, 2007 , # 24 p. 3907 - 3914]

Novel synthesis and spectral characterization of an N-acetoxyarylamine: N-acetoxy-2, 4-dinitrophenylamine

[Huggett, Anthony C.; Cone, James L.; Thorgeirsson, Snorri S.; Roller, Peter P. Journal of Organic Chemistry, 1987 , vol. 52, # 22 p. 4933 - 4937]

Arylamidation de la guanosine par un agent cancérogène, le 2-aminofluorène. Approche intramoléculaire.

[Defrancq, Eric; Leterme, Anne; Pelloux, Nadia; Lhomme, Marie-France; Lhomme, Jean Tetrahedron, 1991 , vol. 47, # 30 p. 5725 - 5736]

In Situ Generation of Nitroso Compounds from Catalytic Hydrogen Peroxide Oxidation of Primary Aromatic Amines and Their One??Pot Use in Hetero??Diels–Alder …

[Yost,Y.; Gutmann,H.R. Journal of the Chemical Society [Section] C: Organic, 1970 , p. 2497 - 2499]

Mechanism-based inactivation of N-arylhydroxamic acid N, O-acyltransferase by 7-substituted-N-hydroxy-2-acetamidofluorenes

[Marhevka, Virginia C.; Ebner, Nancy A.; Sehon, Russell D.; Hanna, Patrick E. Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 18 - 24]

More Articles...