Towards the Synthesis of the 4, 19??Diol Derivative of (–)??Mycothiazole: Synthesis of a Potential Key Intermediate

F Batt, F Fache

Index: Batt, Frederic; Fache, Fabienne European Journal of Organic Chemistry, 2011 , # 30 p. 6039 - 6055

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Citation Number: 6

Abstract

Abstract The synthesis of a potential key intermediate for the synthesis of the 4, 19-diol derivative of (–)-mycothiazole using convergent strategies is described in this paper. Several approaches have been tested, including cross metathesis and a Julia–Kocienski olefination. Finally, the formation of the 1, 1-dialkyl-1, 2-ethanediol motif through C4–C5 bond construction was realized by nucleophilic addition of a vinyl iodide derivative to a keto ...