PdII??Catalyzed Enantioselective Activation of C (sp2) H and C (sp3) H Bonds Using Monoprotected Amino Acids as Chiral Ligands

BF Shi, N Maugel, YH Zhang…

Index: Shi, Bing-Feng; Maugel, Nathan; Zhang, Yang-Hui; Yu, Jin-Quan Angewandte Chemie - International Edition, 2008 , vol. 47, # 26 p. 4882 - 4886

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Citation Number: 261

Abstract

Enantioselective CÀH activation has been a longstanding challenge in catalysis and organic chemistry. The insertion of metal-bound carbenes or nitrenes into CÀH bonds has been employed to develop highly enantioselective carbon–carbon and carbon–nitrogen bond- forming reactions.[1] The enantioselective lithiation of C (sp3) ÀH bonds adjacent to the nitrogen atom in N-tert-butyloxycarbonylpyrrolidine using sec-BuLi/(À) sparteine has ...