Studies on the inactivation of bovine liver enoyl-CoA hydratase by (methylenecyclopropyl) formyl-CoA: elucidation of the inactivation mechanism and identification of …
S Dakoji, D Li, G Agnihotri, H Zhou…
Index: Li, Ding; Zhou, Hui-Qiang; Dakoji, Srikanth; Shin, Injae; Oh, Eugene; Liu, Hung-Wen Journal of the American Chemical Society, 1998 , vol. 120, # 9 p. 2008 - 2017
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Citation Number: 22
Abstract
The inhibitory properties of (methylenecyclopropyl) formyl-CoA (MCPF-CoA), a metabolite derived from a natural amino acid,(methylenecyclopropyl) glycine, against bovine liver enoyl- CoA hydratase (ECH) were characterized. We have previously demonstrated that MCPF- CoA specifically targets ECHs, which catalyze the reversible hydration of α, β-unsaturated enoyl-CoA substrates to the corresponding β-hydroxyacyl-CoA products. Here, we ...
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