The mechanism of alkaline hydrolysis of thiazolidines

R Luhowy, F Meneghini

Index: Luhowy,R.; Meneghini,F. Journal of the American Chemical Society, 1979 , vol. 101, p. 420 - 426

Full Text: HTML

Citation Number: 23

Abstract

Abstract: The kinetics of the alkaline hydrolysis of 2-aryl substituted thiazolidines to aldehydes and aminoethanethiols were measured in 0.001-1.0 M NaOH at 25 OC. While the rates for N-CH3 substituted thiazolidines are linearly dependent on OH-concentration, those for six NH thiazolidines show rate saturation at high OH-concentrations. The mechanism of hydrolysis for NH thiazolidines is interpreted in terms of two equilibrium steps, namely, a ...