Journal of medicinal chemistry

N-Aralkyl substitution of 2-amino-5, 6-and-6, 7-dihydroxy-1, 2, 3, 4-tetrahydronaphthalenes. 2. Derivatives of a hypotensive-positive inotropic agent

DM Stout, RJ Gorczynski

Index: Stout, David M.; Gorczynski, Richard J. Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 326 - 328

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Citation Number: 5

Abstract

Seven derivatives of 2-[[2-(3, 4-dihydroxyphenyl)-l-methylethyl] amino]-6, 7-dihydroxy-l, 2, 3, 4-tetrahydronaphthalene, an inotropic agent which also causes a decrease in blood pressure, were synthesized and tested for inotropic potency, cardioselectivity, and inotropic selectivity. The derivatives were designed to explore whether catechol moieties and rigid rotamers of dopamine are necessary for the activity which was found in the parent ...