Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents
A Kumar, K Srivastava, SR Kumar, SK Puri…
Index: Kumar, Ashok; Srivastava, Kumkum; Raja Kumar; Puri; Chauhan, Prem M.S. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 24 p. 6530 - 6533
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Citation Number: 63
Abstract
The emergence and rapid spread of chloroquine resistant strains of Plasmodium falciparum has dramatically reduced the chemotherapeutic options. Towards this goal, a series of new class of hybrid 4-aminoquinoline triazines were synthesized and screened against CQ sensitive strain 3D7 of P. falciparum in an in vitro model. Compounds 65 and 69 exhibited more than 99% suppression on day 4 and on day 6 post treatment, compound 69 showed ...
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