Journal of the American Chemical Society

The Acylation of Methyl Ketones with Aliphatic Esters by Means of Sodium Amide. Synthesis of β-Diketones of the Type RCOCH2COR1

JT Adams, CR Hauser

Index: Adams; Hauser Journal of the American Chemical Society, 1944 , vol. 66, p. 1222

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Citation Number: 143

Abstract

RCO&aHb 4-CHaCOR--+ RCOCH&OR+ CJ&. OH While acetylations with ethyl acetate have generally been satisfacto0ryJ2 acylations with higher aliphatic esters have previously given only fair yields of the P-diket~ nes.~~* In the present investigation good yields of@- diketones have been obtained from various aliphatic esters and methyl ketones by means of sodium amide. In preliminary experiments using molecular equivalents of ethyl n-butyrate, ...