An efficient synthesis of 4, 5-dihydro-3 (2H)-pyridazinone derivatives
G Tóth, S Molnár, T Tamás, I Borbély
Index: Toth, Gyoergy; Molnar, Sandor; Tamas, Tivadar; Borbely, Ildiko Synthetic Communications, 1997 , vol. 27, # 20 p. 3513 - 3523
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Citation Number: 12
Abstract
Gyorgy T6th*, Sindor Molnir, Tivadar Tamis, Ildiko BorbCly ... Chemical Research Department, Biogal Pharmaceutical Works Ltd., H-4042 Debrecen, Pallagi t 13., Hungary ... Abstract: Reaction of hydrazine with 5-(2-aryl-2-oxo-ethan- 1-yl)-5-R Meldrum's acids 3 gives 4,6-disubstituted 4,5-dihydropyridazin-3(2H)-ones 4 at room temperature. The method is simple and the yield is good. The production of the starting material 3 also is discussed.
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