Tetrahedron

Some 2-fluoroethylamines derived from hydrocinnamic acid, phenylpyruvic acid and DL-phenylalanine

AP Martinez, WW Lee, L Goodman

Index: Martinez,A.P. et al. Tetrahedron, 1964 , vol. 20, p. 2763 - 2771

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Citation Number: 17

Abstract

Fluorine-containing nitrogen mustards attached to hydrocinnamic acid, phenylpyruvic acid and D, L-phenylalanine as carrier groups have been synthesized. The N-(2-chloroethyl)-N- (2′-fluoroethyl) amines are obtained by alkylation of the sodium salts of N- (benzyloxycarbonyl) amines with 2-fluoroethyl p-toluenesulfonate or 2-bromofluorethane, removal of the benzyloxycarbonyl group, followed by hydroxyethylation and chlorination. ...