Norcantharidin analogues with nematocidal activity in Haemonchus contortus

BE Campbell, M Tarleton, CP Gordon, JA Sakoff…

Index: Campbell, Bronwyn E.; Tarleton, Mark; Gordon, Christopher P.; Sakoff, Jennette A.; Gilbert, Jayne; McCluskey, Adam; Gasser, Robin B. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3277 - 3281

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Citation Number: 27

Abstract

Abstract With the major problems with resistance in parasitic nematodes of livestock to anthelmintic drugs, there is an urgent need to develop new nematocides. In the present study, we employed a targeted approach for the design of a series of norcantharidin analogues (n= 54) for activity testing against the barber's pole worm (Haemonchus contortus) of small ruminants in a larval development assay (LDA) and also for toxicity ...