Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction

S Singh, MJ Jedrzejas, GM Air, M Luo…

Index: Singh, Sangetta; Jedrzejas, Marek J.; Air, Gillian M.; Luo, Ming; Laver, W. Graeme; Brouillette, Wayne Journal of Medicinal Chemistry, 1995 , vol. 38, # 17 p. 3217 - 3225

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Citation Number: 87

Abstract

Influenza virus sialidase is a surface enzyme that is essential for infection of the virus. The catalytic site is highly conserved among all known influenza variants, suggesting that this protein is a suitable target for drug intervention. The most potent known inhibitors are analogs of 2-deoxy-2, 3-didehydro-N-acetylneuraminic acid (NeuEiAcBen), particularly the 4- guanidino derivative (4-guanidino-Neu5Ac2en). We utilized the benzene ring of 4-(N- ...