6, 9-Bis [(aminoalkyl) amino] benzo [g] isoquinoline-5, 10-diones. A novel class of chromophore-modified antitumor anthracene-9, 10-diones: synthesis and antitumor …

…, Z Getahun, JJ Landi Jr, J Stallman…

Index: Krapcho, A. Paul; Petry, Mary E.; Getahun, Zelleka; Landi, John J.; Stallman, John; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 6 p. 828 - 837

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Citation Number: 116

Abstract

Synthetic procedures have been developed which lead to the 2-aza congeners 3 and several related N-oxides 4. The analogues 3 exhibited a wide range of in uitro cytotoxicity against L1210 leukemia, the human colon adenocarcinoma cell line LoVo, and the doxorubicin resistant LoVo/DX cell line. Selected analogues of 3 showed significant P388 antileukemic activity in mice with 3c exhibiting high activity. This activity was also retained ...