The Journal of Organic Chemistry

An improved synthesis of anti-benzo [c] phenanthrene-3, 4-diol 1, 2-epoxide via 4-methoxybenzo [c] phenanthrene

B Misra, S Amin

Index: Misra, Bijay; Amin, Shantu Journal of Organic Chemistry, 1990 , vol. 55, # 14 p. 4478 - 4480

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Citation Number: 25

Abstract

Benzo [c] phenanthrene (1) is a relatively weak carcinogen'widely distributed in the environment. 2 Metabolism of 1 on the benzo ring occurs almost exclusively at the 3, 4- position to give trans-benzo [c] phenanthrene-3, 4-diol3 (2), the precursor to the bay region benzo [c]-phenanthrene-3, 4-diol 1, 2-epoxides (BcPhDE). BcPhDE exists as a pair of diastereoisomers: syn-BcPhDE (3) and