Spontaneous hydroxylation of a cyclization intermediate of allopurinol

H Rosemeyer, K Kaiser, F Seela

Index: Seela; Bussmann; Goetze 1982 , vol. No. 4, p. 805 - 812

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Citation Number: 15

Abstract

Phase-transfer methylation of 4-methoxy-lH-pyrazolo [3, 4-d] pyrimidine (2b) leads to a 2: l mixture of the N-1 and the N-2 methylated chromophores (3, 4). Both were found to be converted to the corresponding methylated allopurinol derivatives (5, 6) by nucleophilic