Tetrahedron

An improved synthesis of substituted benzo [b] thiophen-2-carboxylic acids and related acids

PM Chakrabarti, NB Chapman, K Clarke

Index: Chakrabarti,P.M. et al. Tetrahedron, 1969 , vol. 25, p. 2781 - 2785

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Citation Number: 14

Abstract

The oxidative cyclization of β-Aryl-α-mercaptoacrylic acids with chlorine in dry carbon tetrachloride rapidly gives the corresponding benzo [b] thiophen-2-carboxylic acids in high yield. This process is a considerable improvement on processes previously reported. The purity of the crude β-aryl-α-mercaptoacrylic acids can be determined by titration with iodine in ethanol and thus the crude intermediates can be cyclized without further purification by ...