Larvicidal isoxazoles: synthesis and their effective susceptibility towards Aedes aegypti larvae

DCB da Silva-Alves, JV dos Anjos…

Index: Da Silva-Alves, Diana C.B.; Dos Anjos, Janaina V.; Cavalcante, Nery N.M.; Santos, Geanne K.N.; Navarro, Daniela M.Do A.F.; Srivastava, Rajendra M. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 940 - 947

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Citation Number: 9

Abstract

Twenty 3, 5-disubstituted isoxazoles have been synthesized and tested against fourth instar Aedes aegypti larvae. In the synthesis of title compounds, modifications have been made in the C-5 side-chain with a view to test their larvicidal activity. These isoxazoles have been obtained by 1, 3-dipolar cycloaddition of arylnitrile oxides to terminal alkynes which furnished the desired products in 20% to 79% yields. A comparative study of the larvicidal ...