The Journal of Organic Chemistry

Rapid method of preparation of phospholanium perchlorates via intramolecular cyclizations of 4-hydroxybutylorganophosphines

WR Purdum, KD Berlin

Index: Purdum,W.R.; Berlin,K.D. Journal of Organic Chemistry, 1975 , vol. 40, p. 2801 - 2806

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Citation Number: 15

Abstract

A rapid synthetic procedure for the preparation of phospholanium perchlorates in high yield has been developed. The process involves the cleavage of tetrahydrofuran by lithium organophosphides, affording 4-hydroxybutylorganophosphines, which are then intramolecularly cyclized in an aqueous solution. The following phospholanirim salts (very tediously prepared by other methods) have been obtained by this procedure: ...