Further studies toward the stereocontrolled synthesis of silicon-containing peptide mimics

…, L Nielsen, T Mittag, K Bjerglund, S Friis…

Index: Hernandez, Dacil; Lindsay, Karl B.; Nielsen, Lone; Mittag, Tina; Bjerglund, Klaus; Friis, Stig; Mose, Rasmus; Skrydstrup, Troels Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3283 - 3293

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Citation Number: 19

Abstract

Further studies are reported on the utilization of the versatile reaction between chiral sulfinimines and alkyldiphenylsilyl lithium reagents with the goal of preparing a wide range of silanediol-based protease inhibitors. In particular, focus has been placed to demonstrate how a number of genetically encoded amino acid side chains such as serine, threonine, tyrosine, lysine, proline, arginine, aspartate and asparagine might be incorporated into the ...