Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase

…, D Poeckel, D Steinhilber, R Troschuetz…

Index: Landwehr, Jens; George, Sven; Karg, Eva-Maria; Poeckel, Daniel; Steinhilber, Dieter; Troschuetz, Reinhard; Werz, Oliver Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4327 - 4332

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Citation Number: 40

Abstract

Compounds that inhibit 5-lipoxygenase (5-LO), the key enzyme in the biosynthesis of leukotrienes (LTs), possess potential for the treatment of inflammatory and allergic diseases as well as of atherosclerosis and cancer. Here we present the design and the synthesis of a series of novel 2-amino-5-hydroxyindoles that potently inhibit isolated human recombinant 5- LO as well as 5-LO in polymorphonuclear leukocytes, exemplified by ethyl 2-[(3- ...