Potent N-(1, 3-thiazol-2-yl) pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for …

MT Bilodeau, AE Balitza, TJ Koester…

Index: Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6363 - 6372

Full Text: HTML

Citation Number: 48

Abstract

... Journal of Medicinal Chemistry. ... This paper will address the optimization to decrease affinity for the hERG channel and to achieve compounds with excellent in vivo potency and excellent pharmacokinetics in three species. figure Figure 1 Lead structures. Chemistry. ...