Bioorganic & medicinal chemistry

Synthesis of phosphono analogues of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate

P Page, C Blonski, J Périé

Index: Page, Patrick; Blonski, Casimir; Perie, Jacques Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 7 p. 1403 - 1412

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Citation Number: 27

Abstract

The present paper describes the synthetic routes of six phosphono analogues of dihydroxyacetone phosphate and five phosphono analogues of glyceraldehyde 3- phosphate through α-, β-and γ-hydroxyphosphonate esters precursors containing a protected carbonyl group. In some situations, depending on the sequence used for the deprotection of the phosphonate and carbonyl groups, the aldol/ketol rearrangement ...