Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities

KS Kim, SD Kimball, RN Misra…

Index: Journal of Medicinal Chemistry, , vol. 45, # 18 p. 3905 - 3927

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Citation Number: 153

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. 2-Amino-5-thiocyanatothiazole 2 was prepared by reacting 2-aminothiazole with sodium thiocyanate and bromine (Scheme 1). 12 Acylation of the 2-amino-5-thiocyanatothiazole ...

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