A robust process for an mGluR5 negative allosteric modulator: Difluoromethylation and Sonogashira coupling on large scale

JB Sperry, RM Farr, M Levent, M Ghosh…

Index: Organic Process Research and Development, , vol. 16, # 11 p. 1854 - 1860

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Citation Number: 10

Abstract

... First, both the organic and aqueous layers were so black that observing the phase split ... losses, and residual water interfered with the crystallization during initial development on this process. ... An aqueous procedure was developed that involved adding 7 wt % (with respect to 3 ...