[18 F] FMDAA1106 and [18 F] FEDAA1106: two positron-Emitter labeled ligands for peripheral benzodiazepine receptor (PBR)

…, J Maeda, K Furutsuka, Y Yoshida, M Ogawa…

Index: Zhang, Ming Rong; Maeda, Jun; Furutsuka, Kenji; Yoshida, Yuichiro; Ogawa, Masanao; Suhara, Tetsuya; Suzuki, Kazutoshi Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 201 - 204

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Citation Number: 70

Abstract

We synthesized and evaluated N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F] fluoromethyl-5- methoxybenzyl) acetamide ([18F]-FMDAA1106) and N-(5-fluoro-2-phenoxyphenyl)-N-(2- [18F] fluoroethyl-5-methoxybenzyl) acetamide ([18F] FEDAA1106) as two potent radioligands for peripheral benzodiazepine receptors (PBR).[18F] FMDAA1106 and [18F] FEDAA1106 were respectively synthesized by fluoroalkylation of the desmethyl precursor ...