Multisubstituted indole–acrylonitrile hybrids as potential cytotoxic agents

S Ke, Z Yang, Z Zhang, Y Liang, K Wang, M Liu…

Index: Ke, Shaoyong; Yang, Ziwen; Zhang, Zhigang; Liang, Ying; Wang, Kaimei; Liu, Manli; Shi, Liqiao Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 8 p. 1907 - 1911

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Citation Number: 4

Abstract

Abstract A series of multisubstituted indole–acrylonitrile hybrids were designed, synthesized and evaluated for their potential cytotoxic activities. The bio-evaluation results indicated that some of the target compounds (such as 3a, 3f, 3k, 3n) exhibited good to moderate cytotoxic effect on HepG2, BCG-823, BEL-7402, and HL-7702 cell lines. Especially, the compounds 3a and 3k also exhibited high cytotoxic activities (3a, 19.38±3.38 μM; 3k, 15.43±3.54 μM) ...